Some cleaners work against each other, not with each other.
The Two Cleaners You Should Never Mix
How to clean a toilet the safe way, and the one thing you should never mix.

Nobody looks forward to cleaning a toilet. It isn't pleasant, and it can feel like there's no good place to start.
There is a good place to start, though: the cleaner. After that, most of the work happens on its own while you do something else. You just need to know the order, and the one rule that keeps you safe.
Let the cleaner sit first

Squirt toilet bowl cleaner under the rim, all the way around. Let it sit for 5 to 10 minutes before you touch a brush.
Cleaner needs time to break down what's stuck to the bowl. Waiting does most of the scrubbing for you.
Wipe the outside while it works

While the bowl cleaner sits, spray the tank, the lid, and the outside of the bowl with an all-purpose or bathroom cleaner. Wipe it down with a cloth or paper towel.
This is the part everyone's hands touch. It gets dirty faster than the bowl does, and this is the moment to get to it without adding an extra step later.
Never add a second cleaner to the bowl
If the bowl still needs help, add more of the same cleaner. Never pour in a second product, especially bleach, while another cleaner is already in the bowl.
Mixing bleach with an ammonia-based cleaner or with vinegar makes a gas that can hurt your lungs. If a bowl needs more than one pass, flush first, then start again with a single cleaner.
Scrub from under the rim down

Scrub in this order: under the rim, the inside walls, the water line, then the bottom of the bowl.
Working top to bottom means anything you loosen higher up gets caught by the brush lower down, instead of left behind.
Clean the seat, top to bottom

Lift the seat and wipe both sides, then the hinges, then close it and wipe the top. Finish with the flush handle.
Hinges collect grime that a quick wipe misses, and the flush handle is usually the last thing touched, not the first, so it's saved for last here too.
Wipe the base and the floor around it

Wipe the base of the toilet and the floor around it, front and both sides, with a damp cloth or a floor wipe.
Splashes land there more than anywhere else in the room, even when the rest looks clean.
Flush and take a last look
Flush once to rinse the bowl, then look inside. If a spot is still there, one more pass with the brush usually finishes it.
Standing water can hide a streak until it's rinsed clear.
On a low-energy day
Squirt the bowl cleaner, let it sit, and give the seat one wipe. That's enough for now.
The larger lesson
A toilet teaches a rule that works everywhere else in the house too: never guess what's in two bottles at once. Read the label, use one cleaner at a time, and let it do the waiting instead of you doing the scrubbing.

A little patience, one cleaner at a time, and a bowl that's actually clean.
